As Ozempic Use Grows Across Europe, Lesser-Known Risks Emerge | Ozempic Known Risks

From the bustling pharmacies of London to the specialist clinics of Munich, the demand for Ozempic (semaglutide) continues to soar. While its benefits for weight loss and type 2 diabetes are well-documented, the massive scale of its use is bringing rarer, more complex side effects to light. European health agencies are now monitoring reports of conditions that go beyond the common nausea and gastrointestinal issues.

For patients in cities like Barcelona, Dublin, and Rome, understanding these emerging risks is crucial for making an informed decision alongside their healthcare provider.

5 Ozempic Known Risks:

1. Severe Gastrointestinal Complications: More Than Just Nausea

While an upset stomach is a known side effect, regulators are seeing an increase in reports of more severe gastrointestinal events. The European Medicines Agency (EMA) is reviewing cases that suggest a higher incidence of:

• Gastroparesis (“Stomach Paralysis”): This condition severely delays stomach emptying, causing persistent nausea, vomiting, and abdominal pain. A patient in Copenhagen reported being hospitalised after weeks of uncontrollable symptoms, despite being on a standard dose.

• Cyclic Vomiting Syndrome: Characterised by sudden, severe bouts of vomiting that can last for days. Specialists in Amsterdam have noted a curious rise in new-onset cases coinciding with GLP-1 agonist use.

These conditions can be debilitating and may persist even after stopping the medication. Patients experiencing severe, persistent GI issues should seek immediate medical attention.

2. The “Ozempic Face” Phenomenon and Its Deeper Implications

What began as a buzzword in clinics in London and Paris is now a recognised concern: significant facial fat loss (lipoatrophy), leading to an aged, gaunt appearance. However, this is more than a cosmetic issue.

• A Sign of Sarcopenia: The loss of fat in the face often parallels the loss of lean muscle mass throughout the body, a condition known as sarcopenia. This is a serious health risk, as it can weaken patients and slow their metabolism, making long-term weight maintenance difficult.

• Nutritional Guidance is Key: Dietitians in Milan emphasise that a high-protein diet and strength-training exercises are non-negotiable for anyone on Ozempic to help preserve muscle mass.

For a balanced view of what to expect, read our guide to the Pros and Cons of Semaglutide for Weight Loss.

3. Pancreatitis and Gallbladder Disease

These remain rare but serious risks that require vigilance. The UK’s Medicines and Healthcare products Regulatory Agency (MHRA) continues to list acute pancreatitis as a potential side effect. Patients in Edinburgh and Cardiff are advised to seek immediate help if they experience severe, persistent abdominal pain that radiates to the back, as this can be a symptom.

4. Mental Health Considerations: A Nuanced Picture

The link between GLP-1 drugs and mental health is complex. While some patients in Berlin report improved well-being due to weight loss, others experience low mood or anxiety. It is essential to discuss your mental health history with your doctor before starting treatment.

5. Suicidal Ideation: An Ongoing Monitoring Priority

Although a direct causal link has not been firmly established for semaglutide, the EMA is conducting a safety review of all GLP-1 receptor agonists regarding potential suicidal thoughts. This is a standard precautionary measure, but it underscores the need for patients and families to be aware of any sudden changes in mood or behaviour.

Navigating Risks in Your European City: A Patient’s Guide

The key to safely using Ozempic is informed vigilance. Here’s what you can do:

1. Choose a Reputable Provider: Whether you’re in Lisbon or Warsaw, ensure your prescription comes from a licensed medical professional who can provide ongoing monitoring.

2. Start Low, Go Slow: Adhering to the recommended titration schedule helps your body adjust and can mitigate some risks.

3. Report Side Effects: Report any unusual or severe side effects to your doctor and your national pharmacovigilance agency (e.g., the MHRA Yellow Card scheme in the UK, or the EMA’s EudraVigilance system).

Exploring Alternatives in a Changing Landscape

For those concerned about these emerging risks, the market is evolving. Newer medications like Mounjaro (tirzepatide) offer a different mechanism of action, which may suit some patients better. Our comparison of Tirzepatide vs. Semaglutide provides a detailed analysis.

It is more important than ever to have a complete picture of all available options. Explore the full range of modern treatments in our comprehensive Weight Loss Medications hub.